A recent study published in JAMA Cardiology has revealed a potential connection between cannabis use—both through smoking and THC-infused edibles—and an increased risk of heart disease. The research involved 55 participants, divided into two groups: those who consumed marijuana and those who did not. All participants were non-smokers of tobacco and had no exposure to secondhand smoke.
The study focused on the impact of THC on vascular health, particularly examining endothelial dysfunction, a condition where the inner lining of blood vessels does not function properly. This dysfunction can lead to plaque buildup in veins, heightening the risk of heart attacks and other cardiovascular emergencies.
Results indicated that participants who smoked marijuana experienced a 42% reduction in vascular function, while those who consumed THC edibles faced a 56% reduction compared to non-users. Senior author Matthew Springer emphasized that while the study establishes a link between THC use and poor vascular function, it does not definitively prove causation. He noted that similar impairments are also observed in tobacco smokers, suggesting that both the act of smoking and the chemical properties of THC may contribute to cardiovascular issues.
Dr. Leila Mohammadi, another lead author, highlighted the concerning decline in vascular function among cannabis users. She stated, ‘These findings suggest that both smoking and THC consumption adversely impact vascular health.’
Previous research conducted by the American Heart Association in 2023 also indicated a correlation between cannabis use and an elevated risk of heart attacks and strokes, alongside potential heart failure. Another study published in 2025 reported that marijuana users were approximately six times more likely to suffer a heart attack, with an associated increased risk of mortality following such incidents.
While this recent study is relatively small, it adds to the growing body of evidence suggesting that cannabis consumption may pose risks to cardiovascular health. Further research is necessary to fully understand the implications of these findings and the mechanisms at play.
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