{"id":4426,"date":"2025-04-03T01:30:00","date_gmt":"2025-04-03T01:30:00","guid":{"rendered":"https:\/\/weedman.ai\/?p=4426"},"modified":"2025-04-03T19:55:38","modified_gmt":"2025-04-03T19:55:38","slug":"dlouhodoba-studie-ukazuje-ze-lecebne-konopi-zlepsuje-pohodu-pacientu-po-cely-rok","status":"publish","type":"post","link":"https:\/\/weedman.ai\/cs\/novinky\/lek\/2025\/04\/03\/dlouhodoba-studie-ukazuje-ze-lecebne-konopi-zlepsuje-pohodu-pacientu-po-cely-rok\/","title":{"rendered":"Dlouhodob\u00e1 studie ukazuje, \u017ee l\u00e9\u010debn\u00e9 konop\u00ed zlep\u0161uje pohodu pacient\u016f po cel\u00fd rok"},"content":{"rendered":"

Ned\u00e1vn\u00e1 dlouhodob\u00e1 studie zjistila, \u017ee l\u00e9\u010debn\u00e9 konop\u00ed v\u00fdrazn\u011b zlep\u0161uje kvalitu \u017eivota pacient\u016f trp\u00edc\u00edch chronick\u00fdmi onemocn\u011bn\u00edmi. Iniciativa QUEST, kterou provedli v\u011bdci z univerzity v Sydney, sledovala pacienty po dobu 12 m\u011bs\u00edc\u016f, aby zjistila, zda p\u0159\u00ednosy pozorovan\u00e9 b\u011bhem prvn\u00edch t\u0159\u00ed m\u011bs\u00edc\u016f u\u017e\u00edv\u00e1n\u00ed konopn\u00e9ho oleje mohou b\u00fdt trval\u00e9. Zji\u0161t\u011bn\u00ed zve\u0159ejn\u011bn\u00e1 v \u010dasopise PLOS One ukazuj\u00ed, \u017ee u t\u011bch, kte\u0159\u00ed v l\u00e9\u010db\u011b pokra\u010dovali, doch\u00e1zelo k trval\u00e9mu zlep\u0161en\u00ed fyzick\u00e9ho i du\u0161evn\u00edho zdrav\u00ed.<\/p>\n\n\n\n

Mnoho osob \u017eij\u00edc\u00edch s chronick\u00fdmi onemocn\u011bn\u00edmi \u010del\u00ed ka\u017edodenn\u00edm probl\u00e9m\u016fm, v\u010detn\u011b neust\u00e1l\u00e9 bolesti, poruch sp\u00e1nku a emo\u010dn\u00edho stresu. Tradi\u010dn\u00ed l\u00e9\u010dba \u010dasto p\u0159in\u00e1\u0161\u00ed jen omezenou \u00falevu a vedlej\u0161\u00ed \u00fa\u010dinky dlouhodob\u00fdch l\u00e9k\u016f mohou d\u00e1le sni\u017eovat kvalitu \u017eivota pacienta. Jako potenci\u00e1ln\u00ed alternativa se objevilo l\u00e9\u010debn\u00e9 konop\u00ed, kter\u00e9 nab\u00edz\u00ed novou nad\u011bji pro ty, kte\u0159\u00ed nereaguj\u00ed na konven\u010dn\u00ed l\u00e9\u010dbu.<\/p>\n\n\n\n

Od roku 2016, kdy Austr\u00e1lie legalizovala l\u00e9\u010debn\u00e9 konop\u00ed pro pacienty, kte\u0159\u00ed nereaguj\u00ed na standardn\u00ed l\u00e9\u010dbu, bylo konop\u00ed p\u0159edeps\u00e1no v\u00edce ne\u017e milionu lid\u00ed na v\u00edce ne\u017e 200 zdravotn\u00edch pot\u00ed\u017e\u00ed. V\u011bt\u0161ina pacient\u016f ho u\u017e\u00edv\u00e1 k l\u00e9\u010db\u011b bolesti, poruch sp\u00e1nku, \u00fazkosti nebo deprese. L\u00e9\u010debn\u00e9 \u00fa\u010dinky konop\u00ed poch\u00e1zej\u00ed ze slou\u010denin, jako je THC a CBD, kter\u00e9 p\u0159edstavuj\u00ed alternativu k opioidn\u00edm l\u00e9k\u016fm, je\u017e s sebou nesou rizika, jako je z\u00e1vislost a pokles kognitivn\u00edch funkc\u00ed.<\/p>\n\n\n\n

Studie QUEST zahrnovala \u00fa\u010dastn\u00edky ve v\u011bku 18 a\u017e 97 let ze 114 klinik v obdob\u00ed od listopadu 2020 do prosince 2021. \u00da\u010dastn\u00edci absolvovali pravideln\u00e9 hodnocen\u00ed na za\u010d\u00e1tku studie, po dvou t\u00fddnech a v dal\u0161\u00edch osmi \u010dasov\u00fdch bodech a\u017e do 12 m\u011bs\u00edc\u016f. Pod\u00e1vali zpr\u00e1vy o kvalit\u011b \u017eivota souvisej\u00edc\u00ed se zdrav\u00edm (HRQL), zahrnuj\u00edc\u00ed fyzickou, emocion\u00e1ln\u00ed a kognitivn\u00ed pohodu, jako\u017e i ukazatele jako \u00fanava, bolest, sp\u00e1nek, \u00fazkost a deprese.<\/p>\n\n\n\n

V\u00fdsledky studie uk\u00e1zaly jasn\u00e9 zlep\u0161en\u00ed. Sk\u00f3re HRQL se rychle zlep\u0161ilo a z\u016fstalo vysok\u00e9 po celou dobu studie. Konkr\u00e9tn\u011b se sk\u00f3re EQ-5D-5L zv\u00fd\u0161ilo o 0,114 bodu (Cohenovo d = 0,52) a sk\u00f3re QLQ-C30 vzrostlo o 10,71 bodu (d = 0,91), co\u017e nazna\u010duje v\u00fdznamn\u00e9 klinick\u00e9 zlep\u0161en\u00ed. Intenzita bolesti a interference se v\u00fdrazn\u011b sn\u00ed\u017eily, zejm\u00e9na u pacient\u016f s chronickou bolest\u00ed, p\u0159i\u010dem\u017e sk\u00f3re interference bolesti PROMIS se zlep\u0161ilo o 4,87 bodu (d = 0,76). Krom\u011b toho klesla m\u00edra \u00fanavy o 4,70 bodu (d = 0,51) a poruchy sp\u00e1nku se sn\u00ed\u017eily o 5,96 bodu (d = 0,76).<\/p>\n\n\n\n

V\u00fdznamn\u00fd p\u0159\u00ednos l\u00e9\u010debn\u00e9ho konop\u00ed zaznamenali tak\u00e9 pacienti s \u00fazkost\u00ed a depres\u00ed. U osob s depresivn\u00edmi poruchami do\u0161lo ke sn\u00ed\u017een\u00ed sk\u00f3re deprese o 7,19 bodu (d = 0,65), co\u017e u mnoha \u00fa\u010dastn\u00edk\u016f vedlo k posunu z t\u011b\u017ek\u00fdch na st\u0159edn\u011b t\u011b\u017ek\u00e9 p\u0159\u00edznaky. Podobn\u011b se sk\u00f3re \u00fazkosti zlep\u0161ilo o 5,65 bodu (d = 0,69), co\u017e p\u0159ekro\u010dilo klinicky uzn\u00e1vanou hranici 5 bod\u016f.<\/p>\n\n\n\n

Studie tak\u00e9 zjistila, \u017ee pom\u011br THC a CBD v konopn\u00fdch olej\u00edch ovliv\u0148uje v\u00fdsledky. Oleje s p\u0159evahou THC byly spojeny s v\u011bt\u0161\u00edm zlep\u0161en\u00edm \u00fazkosti, deprese, \u00fanavy a sp\u00e1nku, zat\u00edmco oleje s p\u0159evahou CBD byly \u00fa\u010dinn\u011bj\u0161\u00ed u specifick\u00fdch typ\u016f bolesti, jako jsou bolesti hlavy a bolesti souvisej\u00edc\u00ed s rakovinou. Bolesti pohybov\u00e9ho apar\u00e1tu reagovaly l\u00e9pe na oleje s p\u0159evahou CBD ve srovn\u00e1n\u00ed s t\u011bmi, kter\u00e9 obsahovaly \u010dist\u011b CBD.<\/p>\n\n\n\n

T\u00e9m\u011b\u0159 polovina \u00fa\u010dastn\u00edk\u016f uvedla, \u017ee omezila u\u017e\u00edv\u00e1n\u00ed jin\u00fdch l\u00e9k\u016f na p\u0159edpis, p\u0159i\u010dem\u017e p\u0159ibli\u017en\u011b 22% z nich u\u017e\u00edvalo opioidy v dob\u011b zah\u00e1jen\u00ed studie. Na konci 12 m\u011bs\u00edc\u016f 70% z t\u011bchto pacient\u016f bu\u010f sn\u00ed\u017eilo, nebo zcela ukon\u010dilo u\u017e\u00edv\u00e1n\u00ed opioid\u016f. Osoby s pohybov\u00fdmi poruchami v\u0161ak zaznamenaly zlep\u0161en\u00ed HRQL, ale nevyk\u00e1zaly v\u00fdznamn\u00e9 zm\u011bny ve funkci horn\u00edch kon\u010detin, p\u0159i\u010dem\u017e pr\u016fm\u011brn\u00fd n\u00e1r\u016fst sk\u00f3re \u010dinil pouze 1,43 bodu, co\u017e nespl\u0148uje klinick\u00fd pr\u00e1h pro zlep\u0161en\u00ed.<\/p>\n\n\n\n

Studie tak\u00e9 zjistila, \u017ee m\u00edra vypln\u011bn\u00ed v\u00fdsledk\u016f hl\u00e1\u0161en\u00fdch pacientem se v pr\u016fb\u011bhu \u010dasu sni\u017eovala a po 12 m\u011bs\u00edc\u00edch klesla na 38%. Ti, kte\u0159\u00ed l\u00e9\u010dbu ukon\u010dili d\u0159\u00edve, m\u011bli tendenci vykazovat men\u0161\u00ed zlep\u0161en\u00ed, co\u017e nazna\u010duje, \u017ee \u00fa\u010dastn\u00edci, kte\u0159\u00ed v l\u00e9\u010db\u011b pokra\u010dovali, m\u011bli z l\u00e9\u010debn\u00e9ho konop\u00ed v\u011bt\u0161\u00ed prosp\u011bch.<\/p>","protected":false},"excerpt":{"rendered":"

Ned\u00e1vn\u00e1 dlouhodob\u00e1 studie zjistila, \u017ee l\u00e9\u010debn\u00e9 konop\u00ed v\u00fdznamn\u011b zlep\u0161uje kvalitu \u017eivota pacient\u016f trp\u00edc\u00edch chronick\u00fdm...<\/p>","protected":false},"author":2,"featured_media":4425,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[49,71],"tags":[93,215,1136],"class_list":["post-4426","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicine","category-research","tag-chronic-pain","tag-medicinal-cannabis","tag-university-of-sydney"],"yoast_head":"\nLong-term Study Shows Medicinal Cannabis Improves Patient Well-Being for a Full Year - WeedMan<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/weedman.ai\/cs\/novinky\/lek\/2025\/04\/03\/dlouhodoba-studie-ukazuje-ze-lecebne-konopi-zlepsuje-pohodu-pacientu-po-cely-rok\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Long-term Study Shows Medicinal Cannabis Improves Patient Well-Being for a Full Year - 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