Ned\u00e1vn\u00e1 kanadsk\u00e1 studie nazna\u010duje, \u017ee u osob ve v\u011bku 45 let a star\u0161\u00edch, kter\u00e9 pot\u0159ebovaly p\u00e9\u010di na pohotovosti nebo v akutn\u00ed nemocnici kv\u016fli u\u017e\u00edv\u00e1n\u00ed konop\u00ed, se m\u016f\u017ee zv\u00fd\u0161it riziko vzniku demence. V\u00fdzkum, kter\u00fd zahrnoval srovnatelnou kohortu 6 milion\u016f Kana\u010fan\u016f, odhalil, \u017ee u osob, kter\u00fdm byla poskytnuta akutn\u00ed p\u00e9\u010de kv\u016fli u\u017e\u00edv\u00e1n\u00ed konop\u00ed, bylo o 23% vy\u0161\u0161\u00ed riziko, \u017ee jim bude diagnostikov\u00e1na demence, ne\u017e u pacient\u016f, kte\u0159\u00ed vyhledali akutn\u00ed p\u00e9\u010di z jin\u00fdch d\u016fvod\u016f.<\/p>\n\n\n\n
Mezi dosp\u011bl\u00fdmi bez p\u0159edchoz\u00ed anamn\u00e9zy demence bylo riziko nov\u00e9 diagn\u00f3zy demence b\u011bhem p\u011bti let u t\u011bch, kte\u0159\u00ed pot\u0159ebovali akutn\u00ed p\u00e9\u010di kv\u016fli u\u017e\u00edv\u00e1n\u00ed konop\u00ed, 1,5kr\u00e1t vy\u0161\u0161\u00ed ne\u017e u t\u011bch, kte\u0159\u00ed se setkali s akutn\u00ed p\u00e9\u010d\u00ed ze v\u0161ech p\u0159\u00ed\u010din. Konkr\u00e9tn\u011b se jedn\u00e1 o absolutn\u00ed riziko 5% u u\u017eivatel\u016f konop\u00ed ve srovn\u00e1n\u00ed s 3,6% u ostatn\u00edch pacient\u016f, jak vypl\u00fdv\u00e1 ze zji\u0161t\u011bn\u00ed, kter\u00e1 zve\u0159ejnil doktor Daniel Myran, MPH, z Ottawsk\u00e9 univerzity a jeho kolegov\u00e9.<\/p>\n\n\n\n
Studie rovn\u011b\u017e zjistila, \u017ee u osob, kter\u00e9 pot\u0159ebovaly akutn\u00ed p\u00e9\u010di kv\u016fli u\u017e\u00edv\u00e1n\u00ed konop\u00ed, bylo riziko nov\u00e9 diagn\u00f3zy demence 3,9kr\u00e1t vy\u0161\u0161\u00ed ne\u017e u b\u011b\u017en\u00e9 populace, p\u0159i\u010dem\u017e absolutn\u00ed riziko \u010dinilo 5% oproti 1,3%. I po zohledn\u011bn\u00ed sociodemografick\u00fdch faktor\u016f a st\u00e1vaj\u00edc\u00edch zdravotn\u00edch pot\u00ed\u017e\u00ed z\u016fstalo riziko zv\u00fd\u0161en\u00e9. Upraven\u00fd pom\u011br rizika byl 1,23 ve srovn\u00e1n\u00ed s pacienty s akutn\u00ed p\u00e9\u010d\u00ed se v\u0161emi p\u0159\u00ed\u010dinami a 1,72 ve srovn\u00e1n\u00ed s obecnou populac\u00ed, jak bylo uvedeno v \u010dasopise JAMA Neurology.<\/p>\n\n\n\n
Zaj\u00edmav\u00e9 je, \u017ee a\u010dkoli riziko demence v d\u016fsledku u\u017e\u00edv\u00e1n\u00ed konop\u00ed bylo v\u00fdznamn\u00e9, bylo ni\u017e\u0161\u00ed ne\u017e riziko spojen\u00e9 s akutn\u00ed p\u00e9\u010d\u00ed spojenou s alkoholem, kter\u00e9 m\u011blo upraven\u00fd pom\u011br rizik 0,69. Dlouhodob\u00e9 nebo intenzivn\u00ed u\u017e\u00edv\u00e1n\u00ed konop\u00ed ji\u017e bylo spojeno s kognitivn\u00edmi probl\u00e9my ve st\u0159edn\u00edm v\u011bku a zobrazovac\u00ed studie uk\u00e1zaly struktur\u00e1ln\u00ed zm\u011bny v mozku pravideln\u00fdch u\u017eivatel\u016f konop\u00ed.<\/p>\n\n\n\n
Spoluautorka Colleen Webberov\u00e1, PhD., z v\u00fdzkumn\u00e9ho \u00fastavu Ottawsk\u00e9 nemocnice uvedla, \u017ee pravideln\u00e9 u\u017e\u00edv\u00e1n\u00ed konop\u00ed m\u016f\u017ee potenci\u00e1ln\u011b zvy\u0161ovat riziko demence v d\u016fsledku zm\u011bn ve struktu\u0159e mozku. Krom\u011b toho nazna\u010dila, \u017ee m\u016f\u017ee zvy\u0161ovat riziko dal\u0161\u00edch zn\u00e1m\u00fdch rizikov\u00fdch faktor\u016f demence, jako je vysok\u00fd krevn\u00ed tlak, \u00faraz hlavy a soci\u00e1ln\u00ed izolace.<\/p>\n\n\n\n
Studie zahrnovala 6 086 794 Kana\u010fan\u016f ve v\u011bku 45 let a star\u0161\u00edch z Ontaria, kte\u0159\u00ed v dob\u011b za\u0159azen\u00ed do kohorty v letech 2008-2021 nem\u011bli \u017e\u00e1dnou p\u0159edchoz\u00ed anamn\u00e9zu demence. B\u011bhem tohoto \u010dasov\u00e9ho obdob\u00ed dramaticky vzrostl po\u010det n\u00e1v\u0161t\u011bv akutn\u00ed p\u00e9\u010de v d\u016fsledku u\u017e\u00edv\u00e1n\u00ed konop\u00ed, a to p\u011btkr\u00e1t u osob ve v\u011bku 45-64 let a t\u00e9m\u011b\u0159 27kr\u00e1t u osob ve v\u011bku 65 let a star\u0161\u00edch.<\/p>\n\n\n\n
Celkem 16 275 osob, tj. 0,3% studovan\u00e9 skupiny, vyhledalo akutn\u00ed p\u00e9\u010di pr\u00e1v\u011b kv\u016fli u\u017e\u00edv\u00e1n\u00ed konop\u00ed, p\u0159i\u010dem\u017e jejich pr\u016fm\u011brn\u00fd v\u011bk byl 55,2 roku. V\u011bt\u0161ina, 60,3%, byli mu\u017ei a v\u011bt\u0161ina (76,4%) vyu\u017eila p\u00e9\u010di na pohotovosti, zat\u00edmco 23,6% bylo hospitalizov\u00e1no.<\/p>\n\n\n\n
Celkov\u011b tato studie p\u0159in\u00e1\u0161\u00ed d\u016fle\u017eit\u00e9 poznatky o vztahu mezi u\u017e\u00edv\u00e1n\u00edm konop\u00ed a demenc\u00ed, i kdy\u017e auto\u0159i uzn\u00e1vaj\u00ed, \u017ee dosavadn\u00ed v\u00fdzkumy na toto t\u00e9ma jsou omezen\u00e9 a nejednotn\u00e9. Domn\u00edvaj\u00ed se, \u017ee se jedn\u00e1 o dosud nejrozs\u00e1hlej\u0161\u00ed longitudin\u00e1ln\u00ed studii zkoumaj\u00edc\u00ed souvislost mezi akutn\u00ed p\u00e9\u010d\u00ed spojenou s u\u017e\u00edv\u00e1n\u00edm konop\u00ed a diagn\u00f3zou demence.<\/p>\n\n\n\n
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Z ned\u00e1vn\u00e9 kanadsk\u00e9 studie vypl\u00fdv\u00e1, \u017ee osoby ve v\u011bku 45 let a star\u0161\u00ed, kter\u00e9 pot\u0159ebovaly na pohotovosti nebo v akutn\u00ed...<\/p>","protected":false},"author":2,"featured_media":4913,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[49],"tags":[141,101,1525,1524],"class_list":["post-4914","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicine","tag-canada","tag-cannabis-use","tag-dementia","tag-jama-neurology"],"yoast_head":"\n