Ned\u00e1vn\u00e1 studie nazna\u010duje, \u017ee dom\u00e1c\u00ed nervov\u00e1 stimulace pod dohledem m\u016f\u017ee v\u00fdznamn\u011b sn\u00ed\u017eit abstinen\u010dn\u00ed p\u0159\u00edznaky u \u017een s roztrou\u0161enou skler\u00f3zou (RS) a poruchou zp\u016fsobenou u\u017e\u00edv\u00e1n\u00edm konop\u00ed (CUD). T\u00e9to pilotn\u00ed randomizovan\u00e9 kontroln\u00ed studie, publikovan\u00e9 v \u010dasopise Drug and Alcohol Dependence, se z\u00fa\u010dastnilo 47 \u017een s relabuj\u00edc\u00ed-remitentn\u00ed RS v pr\u016fm\u011brn\u00e9m v\u011bku 43 let, kter\u00e9 cht\u011bly sn\u00ed\u017eit p\u0159\u00edjem konop\u00ed.<\/p>\n\n\n\n
P\u0159i z\u00e1kroku byla pou\u017eita transkrani\u00e1ln\u00ed stimulace stejnosm\u011brn\u00fdm proudem (tDCS), neinvazivn\u00ed technika, kter\u00e1 moduluje nervovou aktivitu p\u016fsoben\u00edm slab\u00e9ho elektrick\u00e9ho proudu na mozek. \u00da\u010dastn\u00edci obdr\u017eeli dom\u00e1c\u00ed za\u0159\u00edzen\u00ed tDCS naprogramovan\u00e9 na 20 minut aktivn\u00ed stimulace nebo na fale\u0161nou stimulaci, kdy bylo za\u0159\u00edzen\u00ed vypnut\u00e9. B\u011bhem \u010dty\u0159 t\u00fddn\u016f se \u00fa\u010dastnili ka\u017edodenn\u00edch sezen\u00ed pod dohledem videochat\u016f, do kter\u00fdch byla za\u0159azena meditace v\u0161\u00edmavosti a relaxa\u010dn\u00ed hudba.<\/p>\n\n\n\n
V\u00fdsledky uk\u00e1zaly, \u017ee intervenci dokon\u010dilo 83% \u00fa\u010dastn\u00edk\u016f, co\u017e dokazuje jej\u00ed proveditelnost pro ty, kte\u0159\u00ed kombinuj\u00ed pr\u00e1ci nebo vzd\u011bl\u00e1n\u00ed. Pozoruhodn\u00e9 je, \u017ee \u00fa\u010dastn\u00edci, kte\u0159\u00ed podstoupili aktivn\u00ed stimulaci, zaznamenali 26% sn\u00ed\u017een\u00ed frekvence u\u017e\u00edv\u00e1n\u00ed konop\u00ed, a to z pr\u016fm\u011brn\u00fdch 5,3 dne t\u00fddn\u011b na 3,9 dne. Kontroln\u00ed skupina vyk\u00e1zala men\u0161\u00ed sn\u00ed\u017een\u00ed, a to z 5,3 na 4,8 dne.<\/p>\n\n\n\n
U osob, kter\u00e9 dost\u00e1valy aktivn\u00ed stimulaci, se v\u00fdznamn\u011b sn\u00ed\u017eila touha po konop\u00ed, depresivn\u00ed n\u00e1lada a p\u0159\u00edznaky neklidu spojen\u00e9 s odvyk\u00e1n\u00edm konop\u00ed. Tato zlep\u0161en\u00ed nav\u00edc p\u0159etrv\u00e1vala a\u017e t\u0159i m\u011bs\u00edce po ukon\u010den\u00ed intervence. Ve skupin\u011b s aktivn\u00ed stimulac\u00ed do\u0161lo tak\u00e9 k v\u00fdrazn\u00e9mu poklesu p\u0159\u00edznak\u016f RS, a\u010dkoli tyto p\u0159\u00ednosy po t\u0159ech m\u011bs\u00edc\u00edch sledov\u00e1n\u00ed nep\u0159etrv\u00e1valy.<\/p>\n\n\n\n
V\u00fdsledky studie nazna\u010duj\u00ed, \u017ee c\u00edlen\u00ed na nervov\u00e9 obvody spojen\u00e9 se z\u00e1vislost\u00ed m\u016f\u017ee nab\u00eddnout \u017eivotaschopn\u00fd p\u0159\u00edstup k l\u00e9\u010db\u011b CUD, zejm\u00e9na u populac\u00ed, jako jsou \u017eeny s RS, kter\u00e9 se mohou pot\u00fdkat se z\u00e1vislost\u00ed na konop\u00ed v d\u016fsledku jeho u\u017e\u00edv\u00e1n\u00ed k l\u00e9\u010db\u011b symptom\u016f. V\u00fdzkumn\u00edci v\u0161ak p\u0159iznali omezen\u00ed, v\u010detn\u011b vzorku tvo\u0159en\u00e9ho v\u00fdhradn\u011b \u017eenami a specifick\u00e9ho podtypu \u00fa\u010dastn\u00edk\u016f s RS. Zd\u016fraznili pot\u0159ebu dal\u0161\u00edho v\u00fdzkumu, kter\u00fd by ur\u010dil \u0161ir\u0161\u00ed pou\u017eitelnost t\u00e9to intervence u r\u016fzn\u00fdch populac\u00ed.<\/p>\n\n\n\n
Budouc\u00ed studie by mohly zkoumat del\u0161\u00ed dobu intervence nebo udr\u017eovac\u00ed protokoly, aby se udr\u017eely pozorovan\u00e9 p\u0159\u00ednosy. Slibn\u00e9 v\u00fdsledky t\u00e9to pilotn\u00ed studie poskytuj\u00ed z\u00e1klad pro budouc\u00ed v\u00fdzkum zam\u011b\u0159en\u00fd na v\u00fdvoj \u00fa\u010dinn\u00fdch strategi\u00ed l\u00e9\u010dby poruch zp\u016fsoben\u00fdch u\u017e\u00edv\u00e1n\u00edm konop\u00ed u osob s komplexn\u00edm zdravotn\u00edm stavem.<\/p>","protected":false},"excerpt":{"rendered":"
Ned\u00e1vn\u00e1 studie nazna\u010duje, \u017ee dom\u00e1c\u00ed nervov\u00e1 stimulace pod dohledem m\u016f\u017ee v\u00fdrazn\u011b sn\u00ed\u017eit abstinen\u010dn\u00ed p\u0159\u00edznaky konop\u00ed u \u017een s roztrou\u0161enou skler\u00f3zou...<\/p>","protected":false},"author":2,"featured_media":6231,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71],"tags":[1819,129,2059,2060],"class_list":["post-6233","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","tag-health","tag-multiple-sclerosis","tag-neural-stimulation","tag-withdrawal"],"yoast_head":"\n