Ned\u00e1vn\u00fd v\u011bdeck\u00fd p\u0159ehled publikovan\u00fd v \u010dasopise Pharmacology & Therapeutics nazna\u010duje, \u017ee kanabinoidy obsa\u017een\u00e9 v l\u00e9\u010debn\u00e9m konop\u00ed by mohly zv\u00fd\u0161it \u00fa\u010dinnost chemoterapie a z\u00e1rove\u0148 sn\u00ed\u017eit jej\u00ed vedlej\u0161\u00ed \u00fa\u010dinky. P\u0159ehled na 23 stran\u00e1ch hodnot\u00ed \u0159adu klinick\u00fdch i preklinick\u00fdch studi\u00ed zam\u011b\u0159en\u00fdch p\u0159edev\u0161\u00edm na n\u00e1dorov\u00e1 onemocn\u011bn\u00ed, jako je glioblastom, r\u016fzn\u00e9 hematologick\u00e9 malignity a rakovina prsu.<\/p>\n\n\n\n
Auto\u0159i studie, v\u011bdci z \u00dastavu farmakologie a toxikologie L\u00e9ka\u0159sk\u00e9ho centra Univerzity v Rostocku v N\u011bmecku, shrnuj\u00ed v\u00fdsledky studie konstatov\u00e1n\u00edm, \u017ee st\u00e1vaj\u00edc\u00ed \u00fadaje nazna\u010duj\u00ed, \u017ee kanabinoidy by mohly zlep\u0161it \u00fa\u010dinnost chemoterapeutik a zm\u00edrnit ne\u017e\u00e1douc\u00ed \u00fa\u010dinky b\u011b\u017en\u011b spojen\u00e9 s l\u00e9\u010dbou rakoviny. V p\u0159ehledu se zd\u016fraz\u0148uje, \u017ee zat\u00edmco p\u0159edklinick\u00e9 studie zkoumaly p\u0159edev\u0161\u00edm toxicitu kanabinoid\u016f na rakovinn\u00e9 bu\u0148ky, je t\u0159eba d\u00e1le zkoumat jejich \u0161ir\u0161\u00ed vliv na imunitn\u00ed syst\u00e9m, angiogenezi (tvorbu nov\u00fdch c\u00e9v) a metastazov\u00e1n\u00ed rakoviny.<\/p>\n\n\n\n
Studie se zam\u011b\u0159uje na dv\u011b hlavn\u00ed oblasti: potenci\u00e1l kanabinoid\u016f zv\u00fd\u0161it \u00fa\u010dinnost chemoterapie a jejich schopnost zm\u00edrnit vedlej\u0161\u00ed \u00fa\u010dinky. P\u0159ehled odkazuje na klinickou studii f\u00e1ze 1b z roku 2021, kter\u00e1 nazna\u010dila, \u017ee pacienti, kte\u0159\u00ed dost\u00e1vali kombinaci THC-CBD v peror\u00e1ln\u00edm spreji a chemoterapeutick\u00e9ho l\u00e9ku temozolomid, m\u011bli lep\u0161\u00ed m\u00edru p\u0159e\u017eit\u00ed ve srovn\u00e1n\u00ed s t\u011bmi, kte\u0159\u00ed konopnou l\u00e9\u010dbu nedost\u00e1vali. Hodnocen\u00ed zahrnuje tak\u00e9 r\u016fzn\u00e9 druhy rakoviny v\u010detn\u011b leuk\u00e9mie, rakoviny k\u016f\u017ee a rakoviny tlust\u00e9ho st\u0159eva a kone\u010dn\u00edku.<\/p>\n\n\n\n
Pokud jde o vedlej\u0161\u00ed \u00fa\u010dinky, zpr\u00e1va se zab\u00fdv\u00e1 dob\u0159e zdokumentovan\u00fdmi antiemetick\u00fdmi vlastnostmi kanabinoid\u016f, kter\u00e9 pom\u00e1haj\u00ed zm\u00edrnit nevolnost - \u010dast\u00fd vedlej\u0161\u00ed \u00fa\u010dinek chemoterapie. Upozor\u0148uje v\u0161ak tak\u00e9 na nov\u00e9 v\u00fdzkumy, kter\u00e9 nazna\u010duj\u00ed, \u017ee kanabinoidy mohou pozitivn\u011b ovliv\u0148ovat dal\u0161\u00ed ne\u017e\u00e1douc\u00ed \u00fa\u010dinky souvisej\u00edc\u00ed s chemoterapi\u00ed, jako je perifern\u00ed neuropatie, nefrotoxicita, kardiotoxicita, cystitida a mukozitida. Krom\u011b toho se kanabinoidy \u010dasto pou\u017e\u00edvaj\u00ed k l\u00e9\u010db\u011b chronick\u00e9 bolesti souvisej\u00edc\u00ed s rakovinou.<\/p>\n\n\n\n
Navzdory t\u011bmto slibn\u00fdm zji\u0161t\u011bn\u00edm auto\u0159i upozor\u0148uj\u00ed, \u017ee interakce mezi kanabinoidy a chemoterapeutiky je slo\u017eit\u00e1 a dosud nen\u00ed zcela objasn\u011bna. Vyz\u00fdvaj\u00ed k proveden\u00ed d\u016fkladn\u011bj\u0161\u00edch klinick\u00fdch studi\u00ed u r\u016fzn\u00fdch typ\u016f rakoviny, aby bylo mo\u017en\u00e9 kanabinoidy ov\u011b\u0159it jako dopl\u0148kovou l\u00e9\u010dbu vedle st\u00e1vaj\u00edc\u00edch chemoterapeutick\u00fdch re\u017eim\u016f. P\u0159ehled vyz\u00fdv\u00e1 k dal\u0161\u00edmu zkoum\u00e1n\u00ed mo\u017en\u00fdch negativn\u00edch interakc\u00ed, kter\u00e9 by mohly vzniknout p\u0159i u\u017e\u00edv\u00e1n\u00ed kanabinoid\u016f s chemoterapi\u00ed, a zd\u016fraz\u0148uje pot\u0159ebu komplexn\u00edch studi\u00ed, kter\u00e9 by zkoumaly vztah mezi r\u016fzn\u00fdmi zp\u016fsoby pod\u00e1v\u00e1n\u00ed kanabinoid\u016f a jejich \u00fa\u010dinnost\u00ed.<\/p>\n\n\n\n
Z\u00e1v\u011bry t\u00e9to studie se shoduj\u00ed se samostatnou metaanal\u00fdzou zve\u0159ejn\u011bnou minul\u00fd m\u011bs\u00edc, kter\u00e1 analyzovala \u00fadaje z 10 641 recenzovan\u00fdch studi\u00ed o l\u00e9\u010debn\u00e9m konop\u00ed a jeho vlivu na symptomy souvisej\u00edc\u00ed s rakovinou. Tato anal\u00fdza zjistila silnou v\u011bdeckou shodu ohledn\u011b l\u00e9\u010debn\u00fdch p\u0159\u00ednos\u016f konop\u00ed, zejm\u00e9na p\u0159i zvl\u00e1d\u00e1n\u00ed p\u0159\u00edznak\u016f spojen\u00fdch s l\u00e9\u010dbou rakoviny. V\u00fdzkumn\u00edci konstatovali, \u017ee na ka\u017edou studii, kter\u00e1 poukazovala na ne\u00fa\u010dinnost, p\u0159ipadaj\u00ed t\u0159i studie, kter\u00e9 prokazuj\u00ed pozitivn\u00ed v\u00fdsledky.<\/p>\n\n\n\n
P\u0159ib\u00fdvaj\u00edc\u00ed d\u016fkazy poukazuj\u00ed na rostouc\u00ed akceptaci konop\u00ed v l\u00e9\u010db\u011b rakoviny, a\u010dkoli st\u00e1le p\u0159etrv\u00e1vaj\u00ed ot\u00e1zky ohledn\u011b dostupnosti a cenov\u00e9 dostupnosti. Zpr\u00e1va N\u00e1rodn\u00edho onkologick\u00e9ho institutu (NCI) uv\u00e1d\u00ed, \u017ee 20% a\u017e 40% pacient\u016f s rakovinou vyu\u017e\u00edv\u00e1 konopn\u00e9 produkty ke zm\u00edrn\u011bn\u00ed vedlej\u0161\u00edch \u00fa\u010dink\u016f souvisej\u00edc\u00edch s l\u00e9\u010dbou, p\u0159i\u010dem\u017e popularita konop\u00ed se sleduje spolu s legalizac\u00ed l\u00e9\u010debn\u00e9ho konop\u00ed v mnoha st\u00e1tech.<\/p>\n\n\n\n
Souhrnn\u011b lze \u0159\u00edci, \u017ee kanabinoidy p\u0159edstavuj\u00ed slibnou mo\u017enost, jak zlep\u0161it chemoterapii a zvl\u00e1dat jej\u00ed vedlej\u0161\u00ed \u00fa\u010dinky, av\u0161ak pro pln\u00e9 pochopen\u00ed jejich potenci\u00e1ln\u00ed role v l\u00e9\u010db\u011b rakoviny je nezbytn\u00fd dal\u0161\u00ed v\u00fdzkum.<\/p>","protected":false},"excerpt":{"rendered":"
Ned\u00e1vn\u00fd v\u011bdeck\u00fd p\u0159ehled publikovan\u00fd v \u010dasopise Pharmacology & Therapeutics nazna\u010duje, \u017ee kanabinoidy obsa\u017een\u00e9 v l\u00e9\u010debn\u00e9m konop\u00ed by mohly zv\u00fd\u0161it...<\/p>","protected":false},"author":2,"featured_media":6559,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71],"tags":[92,2120,1819,1744],"class_list":["post-6562","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","tag-cancer","tag-chemotherapy","tag-health","tag-study"],"yoast_head":"\n